Molecular Biology

pick one paper that is provided and think of follow up experiments from that article. These can be only weakly connected to the article, following up in any kind of direction. I would like you to come up with 2 specific aims for a mock grant that follows from that article. Each aim should include:

1) 1-2 sentence hypothesis/aim that should be very focused and specific (i.e. answered by minimal molecular biology experiments).

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2) Naming one specific molecular or bioinformatic experiment for each aim that you could propose to do to examine the aims. i.e., “qpcr” or “blast the coffee genome for xx”

These should be very short and focused. My goal is to help each of you come up with focused aims before you think about writing a grant on it. The hardest part of science is focusing in on a topic. For instance, consider the aims:

1) I aim to cure cancer

2) How does telomere length affect cancer cells?

3) Does the expression of miR-7 in ovarian cancer affect the expression of its target gene EGFR?

All of those example aims fall under the umbrella of cancer biology, however, only the last aim is a focused, targeted aim that could be answered with a few experiments. I am looking for aims like the last one.

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