Aspirin Tablet

Aspirin is hydrolyzed to salicylic acid and this is excreted in the urine. After injecting an aspirin tablet an individual’s blood plasma concentration of salicylate increases.

Ingesting more aspirin than the recommended dose can cause impaired hearing, vomiting, and rapid breathing. The therapeutic blood plasma levels are below 300 mg L -1, above this level an individual can have symptoms of overdose.

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Question 1: How come salicylic acid soluble in water? I mean, shouldn’t it be converted into glucuronide, and then dissolve in water, then excreted in urine?

Question 2: Aspirin, salicylate, salicylic acid. What are the relationships between these three chemicals? How do they chemically convert to each other? Can you give me some chemical formulas? Get homework help today

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