Epsp and ipsp calculation | Biology homework help

The membrane potential, Em, of a post-synaptic cell can be calculated from the following equation:


equation in attachment



where grest is the leakage current which maintains the resting potential, Erest is the normal resting potential, gE is the conductance due to excitatory post-synaptic channels (e.g., AMPA channels), ErevE is the reversal potential for the excitatory channels, gI is the conductance due to inhibitory post-synaptic channels (e.g., GABA channels) and ErevI is the reversal potential for the inhibitory channels (this equation comes from the equivalence circuit discussed in Lecture 13 & 14, slide 21). Assume grest = 1 milliSiemens, Erest = -65 mV, ErevE = -10 mV, ErevI = -70 mV.

a) If gE at the peak of the EPSP is 2 milliSiemens, what is the height of the EPSP without an IPSP (i.e., what is the change in potential from resting)?

b) If gI at the peak of the IPSP is 1 milliSiemens, what is the change in potential from resting?

c) What is the sum of the peak IPSP voltage change and the peak EPSP voltage change?

d) What is the net change in synaptic potential when an EPSP and IPSP occur simultaneously? Why is your answer different from the simple sum of potentials in part c?

Get 20% Discount on This Paper
Pages (550 words)
Approximate price: -

Try it now!

Get 20% Discount on This Paper

We'll send you the first draft for approval by at
Total price:

How it works?

Follow these simple steps to get your paper done

Place your order

Fill in the order form and provide all details of your assignment.

Proceed with the payment

Choose the payment system that suits you most.

Receive the final file

Once your paper is ready, we will email it to you.

Our Services

Australia Assessments has gained an international reputation of being the leading website in custom assignment writing services. Once you give us the instructions of your paper through the order form, we will complete the rest.


Essay Writing Services

As we work towards providing the best custom assignment services, our company provides assignment services for any type of academic essay. We will help you develop professionally written essays that are rich in content and free from plagiarism.


Admission and Business Papers

Our skilled team of professional writers will ensure that we help you craft a remarkable admission essay for your desired Master's program in your institution of choice. We won't stop there. Once you enter the job market, we will be available to secure you a position at your desired worksite by creating an outstanding portfolio or resume.


Editing and Proofreading

Our editorial team is always available for all editing and proofreading services. They check completed papers by our writers and also provide professional opinions to papers completed by our clients.


Technical papers

We harbor professional academic writers with different qualifications in diverse academic fields. As such, we are capable of handling both simple and technical papers. Ensure that you provide us with correct and complete instructions in the order form.